Get A Practical Guide to Assay Development and High-Throughput PDF

By Taosheng Chen

ISBN-10: 1420070509

ISBN-13: 9781420070507

The improvement of compatible assays, the mixing of applicable know-how, and the powerful administration of the basic infrastructure are all serious to the good fortune of any high-throughput screening (HTS) recreation. even if, few scientists have the multidisciplinary adventure had to keep watch over all points of an HTS drug discovery venture. A useful consultant to Assay improvement and High-Throughput Screening in Drug Discovery integrates the adventure of various specialists who supply primary and sensible assistance throughout a number of situations.

The publication first discusses assay advancements for very important aim periods resembling protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and warmth surprise proteins. It subsequent examines assay advancements for telephone viability, apoptosis, and infectious ailments. The individuals discover the applying of rising applied sciences and platforms, together with image-based excessive content material screening, RNA interference, and first cells. ultimately, they talk about the basic elements of the built-in HTS strategy, comparable to screening automation, compound library administration, the screening of average items from botanical resources, and screening informatics.

Designed to inspire researchers to convey additional advances to the sphere, this quantity offers sensible assistance on easy methods to start up, validate, optimize, and deal with a bioassay meant to display huge collections of compounds. Drawing at the wisdom from specialists actively fascinated by assay improvement and HTS, this can be a source that's either complete and targeted.

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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery (Critical Reviews in Combinatorial Chemistry) by Taosheng Chen

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